Emerging roles for Interleukin-11 in disease

PM Nguyen; SM Abdirahman; TL Putoczki

Journal article

Emerging roles for Interleukin-11 in disease

PM Nguyen, SM Abdirahman, TL Putoczki

Growth Factors | TAYLOR & FRANCIS LTD | Published : 2019

DOI: 10.1080/08977194.2019.1620227

Abstract

Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the ability of IL-11 to stimulate megakaryocytopoiesis, the importance of this cytokine to inflammatory disease and cancers is only just beginning to be uncovered. This review outlines recent advances in our understanding of IL-11 biology, and highlights the development of novel therapeutics with the potential for clinical targeting of signaling by this cytokine in multiple diseases.

University of Melbourne Researchers

Paul Nguyen Author

Tracy Putoczki Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The laboratory of TLP is supported by the Victorian State Government Operational Infrastructure support Support Program and by the National Health and Medical Research Council (NHMRC) of Australia Project Grants (1080498; 1098643; 1147621). TLP is a Victorian Cancer Agency Fellow and WEHI Dyson Bequest Centenary Fellow. This work was also supported by grants from National Health and Medical Research Foundation.